How repetitive are genomes?

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Simple sequences are ubiquitous repetitive components of eukaryotic genomes.

Simple sequences are stretches of DNA which consist of only one, or a few tandemly repeated nucleotides, for example poly (dA) X poly (dT) or poly (dG-dT) X poly (dC-dA). These two types of simple sequence have been shown to be repetitive and interspersed in many eukaryotic genomes. Several other types have been found by sequencing eukaryotic DNA. In this report we have undertaken a systematica...

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Repetitive elements in genomes of parasitic protozoa.

Repetitive DNA elements have been a part of the genomic fauna of eukaryotes perhaps since their very beginnings. Millions of years of coevolution have given repeats central roles in chromosome maintenance and genetic modulation. Here we review the genomes of parasitic protozoa in the context of the current understanding of repetitive elements. Particular reference is made to repeats in five med...

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Highly repetitive DNA sequences in cyanobacterial genomes.

We characterized three distinct families of repeated sequences in the genome of the cyanobacterium Calothrix sp. strain PCC 7601. These repeated sequences were present at a level of about 100 copies per Calothrix genome and consisted of tandemly amplified heptanucleotides. These elements were named short tandemly repeated repetitive (STRR) sequences. We used the three different Calothrix STRR s...

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How Genomes are Sequenced and Why it Matters

Claims about high genomic DNA sequence similarity between humans and chimpanzees are typically made to audiences that do not understand the various layers of technology and ideological bias imposed upon the origination of the data in question. The recent human-chimp Y-chromosome project introduced a number of important genomic tools to achieve a considerably less-biased analysis. The results in...

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Short subsequences in genomes: How random are they?

A comparative statistical analysis of the presence of all possible short subsequences of length 5 to 20 nucleotides in the genomes of more than 250 microbial, viral and multicellular organisms was performed. A remarkable similarity of the presence/absence distributions for different n-mers in all genomes was found. The same analysis applied analytically and numerically to random sequences also ...

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ژورنال

عنوان ژورنال: BMC Bioinformatics

سال: 2006

ISSN: 1471-2105

DOI: 10.1186/1471-2105-7-541